two matrix metalloproteinase inhibitors from scrophularia striata boiss
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abstract
many species belonging to the scrophularia genus have been used since ancient times as folk remedies for many medical conditions such as scrofulas, scabies, tumors, eczema, psoriasis, inflammations. the aim of this study was to characterize the matrix metalloproteinases (mmps) inhibitor compounds of the scrophularia striata extract by bio-guide fractionation. the aerial parts of s. striata were collected and different extracts were sequentially prepared with increasingly polar solvents. the mmps inhibitory activity of the crude extract and its fractions were evaluated by the zymoanalysis method. the pure compounds were purified from the active fraction by chromatography methods. chemical structures were deduced by nuclear magnetic resonance and mass spectrometry. two active compounds (acteoside and nepitrin) were identified by bio-guide fractionation. the inhibitory effects of nepitrin and acteoside at 20 µg/ml were about 56 and 18 percent, respectivly. the inhibitory effects of acteoside at 80 µg/ml were increased to about 73 percent. in summary, the results suggest that nepitrin effectively inhibited mmps inhibitory activity at low concentrations, whereas acteoside showed inhibition at high concentrations.
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Two Matrix Metalloproteinase Inhibitors from Scrophularia Striata Boiss
Many species belonging to the Scrophularia genus have been used since ancient times as folk remedies for many medical conditions such as scrofulas, scabies, tumors, eczema, psoriasis, inflammations. The aim of this study was to characterize the matrix metalloproteinases (MMPs) inhibitor compounds of the Scrophularia striata extract by bio-guide fractionation. The aerial parts of S. striata were...
full textTwo Matrix Metalloproteinase Inhibitors from Scrophularia Striata Boiss
Many species belonging to the Scrophularia genus have been used since ancient times as folk remedies for many medical conditions such as scrofulas, scabies, tumors, eczema, psoriasis, inflammations. The aim of this study was to characterize the matrix metalloproteinases (MMPs) inhibitor compounds of the Scrophularia striata extract by bio-guide fractionation. The aerial parts of S. striata were...
full textTwo Matrix Metalloproteinase Inhibitors from Scrophularia Striata Boiss
Many species belonging to the Scrophularia genus have been used since ancient times as folk remedies for many medical conditions such as scrofulas, scabies, tumors, eczema, psoriasis, inflammations. The aim of this study was to characterize the matrix metalloproteinases (MMPs) inhibitor compounds of the Scrophularia striata extract by bio-guide fractionation. The aerial parts of S. striata were...
full textTotal Phenolic, Total Flavonoids, Antioxidant and Antimicrobial Activities of Scrophularia Striata Boiss Extracts
BACKGROUND Scrophularia striata (Scrophulariaceae family) is an herbaceous plant that is traditionally used for treatment of microbial infections. OBJECTIVES Antimicrobial and antioxidant activity of different extracts (methanolic, ethanolic, aqueous and ethyl acetate) from S. striata aerial parts was evaluated. MATERIALS AND METHODS The antimicrobial activity of different extracts from S. ...
full textبررسی تکوین اندام‌های زایشی در گیاه دارویی تشنه داری Scrophularia striata Boiss.
هدف: بررسی تکوینگلبرایدرکتمایزسلولیوساز و کارهایژنتیکیلازمبرایاندامزاییمناسباست. درپژوهشحاضر تکوین اندام‌های زایشی S. striataبررسیشد. مواد و روش‌ها: غنچه‌هایگل‌درمراحلنموبرداشتشدند،پس از تثبیت درFAA وگذراندن مراحل آبگیری، قالبگیریدرپارافینبامیکروتومبرشگیری و باهماتوکسیلین ـ ائوزین رنگآمیزیشدند. مراحلتکوین اندام زایشی با استفادهازمیکروسکوپنوریبررسی و عکسبرداری شد. نتایج: نتایج نش...
full textشناسایی ترکیب‌های تشکیل‌دهنده اسانس و بررسی ساختارهای ترشحی گیاه Scrophularia striata Boiss.
گونه Scrophularia striata Boiss. متعلق به تیره Scrophulariaceae بوده که در استان لرستان با نام محلی تشنه دارو معروف است. این گیاه از دامنه کوه‌های شمال غرب شهرستان کوهدشت در منطقه تنگ‌سیاب واقع در استان لرستان جمع‌آوری گردید و پس از خشک کردن گیاه در سایه، اسانس‌گیری از بخش‌های هوایی آن شامل ساقه، برگ و میوه با روش تقطیر با آب انجام شد. شناسایی ترکیب‌های موجود در اسانس به وسیله کروماتوگراف گازی ...
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Journal title:
iranian journal of pharmaceutical researchجلد ۱۳، شماره ۱، صفحات ۱۴۹-۱۵۵
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